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GLP-1 injections, including semaglutide and tirzepatide are given with a very small needle and are generally painless or cause minimal discomfort

Administering sermorelin at bedtime (the standard protocol) minimizes the impact of this side effect, as patients are lying down when it occurs

World J Stem Cells 16(1):1 Hu Y, Xu J, jie Shi S, Zhou X, Wang L, Huang L, Gao L, Pang W, Yang G, Chu G (2022) Fibroblast growth factor 21 (FGF21) promotes porcine granulosa cell estradiol production and proliferation via PI3K/AKT/mTOR signaling

It also upregulates antioxidant enzymes including superoxide dismutase (SOD) and catalase